A Memory of Early Life Physical Activity Is Retained in Bone Marrow of Male Rats Fed a High-Fat Diet

نویسندگان

  • Dharani M. Sontam
  • Mark H. Vickers
  • Elwyn C. Firth
  • Justin M. O'Sullivan
چکیده

Studies have reported opposing effects of high-fat (HF) diet and mechanical stimulation on lineage commitment of the bone marrow stem cells. Yet, how bone marrow modulates its gene expression in response to the combined effects of mechanical loading and a HF diet has not been addressed. We investigated whether early-life (before onset of sexual maturity at 6 weeks of age) voluntary physical activity can modulate the effects of a HF diet on male Sprague Dawley rats. In the bone marrow, early-life HF diet resulted in adipocyte hypertrophy and a pro-inflammatory and pro-adipogenic gene expression profile. The bone marrow of the rats that undertook wheel exercise while on a HF diet retained a memory of the early-life exercise. This memory lasted at least 60 days after the cessation of the voluntary exercise. Our results are consistent with the marrow adipose tissue having a unique response to HF feeding in the presence or absence of exercise.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring

Objective(s): Maternal high-fat diet (HFD) is linked with metabolic and cognitive deficits in offspring. Neuroprotective effects of troxerutin, a natural bioflavonoid, have been reported recently. This study aimed to investigate the effects of troxerutin on spatial memory and serum and hippocampal apelin levels in the male offspring of HFD fed mothers.Materials and Methods: Three-week-old femal...

متن کامل

اثر نوع تمرین بر نشانگران آپوپتوز هپاتوسیتی در رت‌های تغذیه شده با غذای پرچربب

Background:Anti-inflammation and anti-apoptotic effects of physical activity have been proven and its effectiveness depends on intensity, duration and type. Since obesity is considered as a mild chronic inflammation, it is reasonable that the degenerative damages occurin tissues, especially in the liver as the center of metabolism. The aim of this study was to investigate the effect of two typ...

متن کامل

Anti-oxidant and anti-hyperlipidemic activity of Hemidesmus indicus in rats fed with high-fat diet

Objective: Dietary changes playmajor risk roles in oxidative stress andcardiovascular disease and modulate normal metabolic function. The present study was designed to investigate the ameliorative potential of different extracts of Hemidesmus indicus to experimental high-fat diet in wistar rats, and their possible mechanism of action.  Materials and Methods: Male wistar rats were divided into 6...

متن کامل

Effects of Endurance Training and Isocaloric High Intensity Interval Training on Anthropometric Indices and Insulin Resistance in High Fat Diet-Fed Wistar Rats

ABSTRACT Background and Objectives: Obesity is a global health problem that could lead to cardiovascular disease, diabetes and cancer. Polygenic obesity is caused by multiple factors, such as lack of exercise and excess food intake. In this study, we evaluated effects of 12 weeks of high-intensity interval training (HIIT) and isocratic moderate-intensity training (MIT) on anthropometric indice...

متن کامل

Investigating the Protective Effect of an Interval Training on Neutrophilic Factors of BDNF and CDNF in Rats Fed with High-fat Foods

Background and Aim: Exercise targets the secretion of brain-derived neurotrophic factors and has a major impact on the overall health of the brain. The present study aimed to investigate the protective effect of a period of interval training on neutrophilic factors of BDNF and CDNF in rats fed with high-fat foods. Materials and Methods: In this experimental study, 42 male Wistar rats were rando...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2017